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Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

Author

Listed:
  • Antonis Kirmizis

    (Tennis Court Road, Cambridge CB2 1QN, UK)

  • Helena Santos-Rosa

    (Tennis Court Road, Cambridge CB2 1QN, UK)

  • Christopher J. Penkett

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Michael A. Singer

    (NimbleGen Systems, Inc., 1 Science Court, Madison, Wisconsin 53711, USA)

  • Michiel Vermeulen

    (Max Planck Institute for Biochemistry)

  • Matthias Mann

    (Max Planck Institute for Biochemistry)

  • Jürg Bähler

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK)

  • Roland D. Green

    (NimbleGen Systems, Inc., 1 Science Court, Madison, Wisconsin 53711, USA)

  • Tony Kouzarides

    (Tennis Court Road, Cambridge CB2 1QN, UK)

Abstract

Methylation of histone H3 on residue Lys4 (H3K4) contributes to transcription activation. Now it is shown that in budding yeast, an adjacent modification, methylated Arg2, can inhibit H3K4 methylation by preventing the binding of a methyl transferase complex.

Suggested Citation

  • Antonis Kirmizis & Helena Santos-Rosa & Christopher J. Penkett & Michael A. Singer & Michiel Vermeulen & Matthias Mann & Jürg Bähler & Roland D. Green & Tony Kouzarides, 2007. "Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation," Nature, Nature, vol. 449(7164), pages 928-932, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7164:d:10.1038_nature06160
    DOI: 10.1038/nature06160
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    Cited by:

    1. Qi Yu & Xuanyunjing Gong & Yue Tong & Min Wang & Kai Duan & Xinyu Zhang & Feng Ge & Xilan Yu & Shanshan Li, 2022. "Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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