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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

Author

Listed:
  • Karl Agger

    (Biotech Research and Innovation Centre (BRIC), and,
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark)

  • Paul A. C. Cloos

    (Biotech Research and Innovation Centre (BRIC), and,
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark)

  • Jesper Christensen

    (Biotech Research and Innovation Centre (BRIC), and,
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark)

  • Diego Pasini

    (Biotech Research and Innovation Centre (BRIC), and,
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark)

  • Simon Rose

    (Biotech Research and Innovation Centre (BRIC), and,)

  • Juri Rappsilber

    (Wellcome Trust Centre for Cell Biology, University of Edinburgh)

  • Irina Issaeva

    (Weizmann Institute of Science)

  • Eli Canaani

    (Weizmann Institute of Science)

  • Anna Elisabetta Salcini

    (Biotech Research and Innovation Centre (BRIC), and,)

  • Kristian Helin

    (Biotech Research and Innovation Centre (BRIC), and,
    Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark)

Abstract

Two human JmjC-domain-containing enzymes are shown to catalyse demethylation of histone H3K27me3, a histone modification mediated by polycomb proteins and associated with stem cell maintenance and differentiation

Suggested Citation

  • Karl Agger & Paul A. C. Cloos & Jesper Christensen & Diego Pasini & Simon Rose & Juri Rappsilber & Irina Issaeva & Eli Canaani & Anna Elisabetta Salcini & Kristian Helin, 2007. "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development," Nature, Nature, vol. 449(7163), pages 731-734, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7163:d:10.1038_nature06145
    DOI: 10.1038/nature06145
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    Cited by:

    1. Marta Vicioso-Mantis & Raquel Fueyo & Claudia Navarro & Sara Cruz-Molina & Wilfred F. J. Ijcken & Elena Rebollo & Álvaro Rada-Iglesias & Marian A. Martínez-Balbás, 2022. "JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Alexandra D’Oto & Jie Fang & Hongjian Jin & Beisi Xu & Shivendra Singh & Anoushka Mullasseril & Victoria Jones & Ahmed Abu-Zaid & Xinyu Buttlar & Bailey Cooke & Dongli Hu & Jason Shohet & Andrew J. Mu, 2021. "KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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