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Snapshots of nuclear pore complexes in action captured by cryo-electron tomography

Author

Listed:
  • Martin Beck

    (Max Planck Institute of Biochemistry)

  • Vladan Lučić

    (Max Planck Institute of Biochemistry)

  • Friedrich Förster

    (Max Planck Institute of Biochemistry)

  • Wolfgang Baumeister

    (Max Planck Institute of Biochemistry)

  • Ohad Medalia

    (Max Planck Institute of Biochemistry
    Present address: The Department of Life Sciences, The Ben Gurion University and the NIBN, Beer Sheva 84105, Israel.)

Abstract

The structure of the nuclear pore complexes in intact nuclei is studied by cryoelectron tomography. The trajectory of cargo molecules was traced used gold-labelled proteins fused to a nuclear localization signal. Superimposition of multiple tomograms has yielded a map outlining the pathway of cargo molecules during import into the nucleus.

Suggested Citation

  • Martin Beck & Vladan Lučić & Friedrich Förster & Wolfgang Baumeister & Ohad Medalia, 2007. "Snapshots of nuclear pore complexes in action captured by cryo-electron tomography," Nature, Nature, vol. 449(7162), pages 611-615, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7162:d:10.1038_nature06170
    DOI: 10.1038/nature06170
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    Cited by:

    1. Ruhollah Moussavi-Baygi & Yousef Jamali & Reza Karimi & Mohammad R K Mofrad, 2011. "Brownian Dynamics Simulation of Nucleocytoplasmic Transport: A Coarse-Grained Model for the Functional State of the Nuclear Pore Complex," PLOS Computational Biology, Public Library of Science, vol. 7(6), pages 1-16, June.

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