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Taking dendritic cells into medicine

Author

Listed:
  • Ralph M. Steinman

    (The Rockefeller University)

  • Jacques Banchereau

    (Baylor Institute for Immunology Research, Dallas, Texas 75204, USA)

Abstract

Cells with connections Dendritic cells are found in the blood and in tissues exposed to the environment, such as the skin and the lining of the nose, lungs and stomach. Their job is to adjust innate and adaptive immune responses to the environmental stimulus at hand. In a review, Ralph Steinman (awarded the Laskar prize last week in recognition of his discovery of dendritic cells) and Jacques Banchereau discuss the medically relevant properties of dendritic cells. Pathogens and tumours can exploit dendritic cells to evade immunity, making them logical drug targets. They can also generate resistance: during allergy, autoimmunity and transplant rejection, dendritic cells may instigate unwanted responses, but they can also silence these conditions.

Suggested Citation

  • Ralph M. Steinman & Jacques Banchereau, 2007. "Taking dendritic cells into medicine," Nature, Nature, vol. 449(7161), pages 419-426, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06175
    DOI: 10.1038/nature06175
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    Cited by:

    1. Sunil K. Ahuja & Muthu Saravanan Manoharan & Grace C. Lee & Lyle R. McKinnon & Justin A. Meunier & Maristella Steri & Nathan Harper & Edoardo Fiorillo & Alisha M. Smith & Marcos I. Restrepo & Anne P. , 2023. "Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection," Nature Communications, Nature, vol. 14(1), pages 1-31, December.
    2. Kristina Lundberg & Ann-Sofie Albrekt & Inge Nelissen & Saskia Santegoets & Tanja D de Gruijl & Sue Gibbs & Malin Lindstedt, 2013. "Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-15, January.

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