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Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

Author

Listed:
  • Marco Seandel

    (Howard Hughes Medical Institute, and
    and)

  • Daylon James

    (Howard Hughes Medical Institute, and)

  • Sergey V. Shmelkov

    (Howard Hughes Medical Institute, and)

  • Ilaria Falciatori

    (Howard Hughes Medical Institute, and)

  • Jiyeon Kim

    (Howard Hughes Medical Institute, and)

  • Sai Chavala

    (Howard Hughes Medical Institute, and)

  • Douglas S. Scherr

    (Weill Cornell Medical College, New York 10065, USA)

  • Fan Zhang

    (Howard Hughes Medical Institute, and)

  • Richard Torres

    (Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA)

  • Nicholas W. Gale

    (Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA)

  • George D. Yancopoulos

    (Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA)

  • Andrew Murphy

    (Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA)

  • David M. Valenzuela

    (Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA)

  • Robin M. Hobbs

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York 10065, USA
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Pier Paolo Pandolfi

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York 10065, USA
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Shahin Rafii

    (Howard Hughes Medical Institute, and)

Abstract

Stem cells make their mark Adult stem cells are an attractive alternative to embryonic stem cells for therapeutic use. As yet there is no standard method for obtaining such cells from adults and priming them to form different tissues, but a new system that generates large numbers of stem cells from the adult testicle shows promise. It makes use of a novel marker, an orphan receptor known as GPR125, found on the surface of spermatogonial stem cells. The use of specialized feeder cells to support stem cell growth allows stem cells once destined for spermatogenesis to become multipotent. This work also provides clues as to the minimal requirements for multipotency in adult cells.

Suggested Citation

  • Marco Seandel & Daylon James & Sergey V. Shmelkov & Ilaria Falciatori & Jiyeon Kim & Sai Chavala & Douglas S. Scherr & Fan Zhang & Richard Torres & Nicholas W. Gale & George D. Yancopoulos & Andrew Mu, 2007. "Generation of functional multipotent adult stem cells from GPR125+ germline progenitors," Nature, Nature, vol. 449(7160), pages 346-350, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7160:d:10.1038_nature06129
    DOI: 10.1038/nature06129
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    Cited by:

    1. Elena Spina & Julia Simundza & Angela Incassati & Anupama Chandramouli & Matthias C. Kugler & Ziyan Lin & Alireza Khodadadi-Jamayran & Christine J. Watson & Pamela Cowin, 2022. "Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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