IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v449y2007i7159d10.1038_nature06115.html
   My bibliography  Save this article

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU

Author

Listed:
  • Mark J. Kiel

    (Howard Hughes Medical Institute, Life Sciences Institute, and Centre for Stem Cell Biology)

  • Shenghui He

    (Howard Hughes Medical Institute, Life Sciences Institute, and Centre for Stem Cell Biology)

  • Rina Ashkenazi

    (University of Michigan, Ann Arbor, Michigan 48109-2216, USA)

  • Sara N. Gentry

    (University of Michigan, Ann Arbor, Michigan 48109-2216, USA)

  • Monica Teta

    (Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Jake A. Kushner

    (Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Trachette L. Jackson

    (University of Michigan, Ann Arbor, Michigan 48109-2216, USA)

  • Sean J. Morrison

    (Howard Hughes Medical Institute, Life Sciences Institute, and Centre for Stem Cell Biology)

Abstract

The not-so-immortal strand In 1975, John Cairns proposed the 'immortal strand' hypothesis as a mechanism by which adult stem cells might minimize accumulation of mutations. This is achieved by selectively retaining chromosomes containing 'old' DNA as shown by the analysis of the DNA strands that incorporate radioactive label or a nucleotide analogue such as bromodeoxyuridine (BrdU). A new contribution to this ongoing debate is published in this issue. Kiel et al. show that the immortal strand model is not a general property of stem cells since it does not apply to haematopoietic stem cells. These cells cannot be identified on the basis of BrdU label retention, and do not retain older DNA during division.

Suggested Citation

  • Mark J. Kiel & Shenghui He & Rina Ashkenazi & Sara N. Gentry & Monica Teta & Jake A. Kushner & Trachette L. Jackson & Sean J. Morrison, 2007. "Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU," Nature, Nature, vol. 449(7159), pages 238-242, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7159:d:10.1038_nature06115
    DOI: 10.1038/nature06115
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06115
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06115?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Richard C van der Wath & Anne Wilson & Elisa Laurenti & Andreas Trumpp & Pietro Liò, 2009. "Estimating Dormant and Active Hematopoietic Stem Cell Kinetics through Extensive Modeling of Bromodeoxyuridine Label-Retaining Cell Dynamics," PLOS ONE, Public Library of Science, vol. 4(9), pages 1-12, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:449:y:2007:i:7159:d:10.1038_nature06115. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.