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Dscam diversity is essential for neuronal wiring and self-recognition

Author

Listed:
  • Daisuke Hattori

    (Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA)

  • Ebru Demir

    (Institute of Molecular Pathology, Dr. Bohr-gasse 7, Vienna A-1030, Austria)

  • Ho Won Kim

    (Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA)

  • Erika Viragh

    (Institute of Molecular Pathology, Dr. Bohr-gasse 7, Vienna A-1030, Austria)

  • S. Lawrence Zipursky

    (Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA)

  • Barry J. Dickson

    (Institute of Molecular Pathology, Dr. Bohr-gasse 7, Vienna A-1030, Austria)

Abstract

Wiring diagram The complexity and specificity of neuronal wiring implies the existence of a cellular recognition code that allows neurons to distinguish between one another. The remarkable diversity of the immunoglobulin superfamily protein Dscam (for Down syndrome cell adhesion molecule) may be part of that system. Dscam plays a crucial role in making Drosophila neurons able to distinguish between self and non-self, and is essential to patterning neural circuits.

Suggested Citation

  • Daisuke Hattori & Ebru Demir & Ho Won Kim & Erika Viragh & S. Lawrence Zipursky & Barry J. Dickson, 2007. "Dscam diversity is essential for neuronal wiring and self-recognition," Nature, Nature, vol. 449(7159), pages 223-227, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7159:d:10.1038_nature06099
    DOI: 10.1038/nature06099
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    Cited by:

    1. Ze Zhang & Fabao Chen & Zihan Zhang & Luqiang Guo & Tingting Feng & Zhen Fang & Lihui Xin & Yang Yu & Hongyu Hu & Yingbin Liu & Yongning He, 2025. "Structural insights into the in situ assembly of clustered protocadherin γB4," Nature Communications, Nature, vol. 16(1), pages 1-12, December.

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