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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

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Listed:
  • Laura E. Parton

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Chian Ping Ye

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Roberto Coppari

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Center for Hypothalamic Research, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9077, USA)

  • Pablo J. Enriori

    (Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA)

  • Brian Choi

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Chen-Yu Zhang

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University)

  • Chun Xu

    (Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA)

  • Claudia R. Vianna

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Nina Balthasar

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Present address: Department of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK.)

  • Charlotte E. Lee

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Joel K. Elmquist

    (Center for Hypothalamic Research, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9077, USA)

  • Michael A. Cowley

    (Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA)

  • Bradford B. Lowell

    (Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA)

Abstract

Mice that cannot sense glucose with their pro-opiomelanocortin (POMC neurons) develop glucose intolerance, demonstrating that glucose sensing in neurons plays an important role in responding to a systemic glucose load. It is also shown that in mice with obesity-induced type 2 diabetes, glucose-sensing by POMC neurons is defective.

Suggested Citation

  • Laura E. Parton & Chian Ping Ye & Roberto Coppari & Pablo J. Enriori & Brian Choi & Chen-Yu Zhang & Chun Xu & Claudia R. Vianna & Nina Balthasar & Charlotte E. Lee & Joel K. Elmquist & Michael A. Cowl, 2007. "Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity," Nature, Nature, vol. 449(7159), pages 228-232, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7159:d:10.1038_nature06098
    DOI: 10.1038/nature06098
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    Cited by:

    1. Maiko Matsui & Lauren E. Lynch & Isabella Distefano & Allison Galante & Aravind R. Gade & Hong-Gang Wang & Nicolas Gómez-Banoy & Patrick Towers & Daniel S. Sinden & Eric Q. Wei & Adam S. Barnett & Ken, 2024. "Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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