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p53 is regulated by the lysine demethylase LSD1

Author

Listed:
  • Jing Huang

    (The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA)

  • Roopsha Sengupta

    (Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria)

  • Alexsandra B. Espejo

    (M. D. Anderson Cancer Center, University of Texas, Smithville, Texas 78957, USA)

  • Min Gyu Lee

    (The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA)

  • Jean A. Dorsey

    (The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA)

  • Mario Richter

    (Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria)

  • Susanne Opravil

    (Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria)

  • Ramin Shiekhattar

    (The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA)

  • Mark T. Bedford

    (M. D. Anderson Cancer Center, University of Texas, Smithville, Texas 78957, USA)

  • Thomas Jenuwein

    (Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, 1030 Vienna, Austria)

  • Shelley L. Berger

    (The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA)

Abstract

LSD1 reverses methylation of p53 at lysine 370 to repress p53-mediated transcriptional activation and apoptosis, and to prevent the interaction of p53 with 53BP1.

Suggested Citation

  • Jing Huang & Roopsha Sengupta & Alexsandra B. Espejo & Min Gyu Lee & Jean A. Dorsey & Mario Richter & Susanne Opravil & Ramin Shiekhattar & Mark T. Bedford & Thomas Jenuwein & Shelley L. Berger, 2007. "p53 is regulated by the lysine demethylase LSD1," Nature, Nature, vol. 449(7158), pages 105-108, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7158:d:10.1038_nature06092
    DOI: 10.1038/nature06092
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    Cited by:

    1. Ramachandran Prakasam & Angela Bonadiman & Roberta Andreotti & Emanuela Zuccaro & Davide Dalfovo & Caterina Marchioretti & Debasmita Tripathy & Gianluca Petris & Eric N. Anderson & Alice Migazzi & Lau, 2023. "LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Wen Juan Tu & Michelle Melino & Jenny Dunn & Robert D. McCuaig & Helle Bielefeldt-Ohmann & Sofiya Tsimbalyuk & Jade K. Forwood & Taniya Ahuja & John Vandermeide & Xiao Tan & Minh Tran & Quan Nguyen & , 2023. "In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Meng Xu & Dulmi Senanayaka & Rongwei Zhao & Tafadzwa Chigumira & Astha Tripathi & Jason Tones & Rachel M. Lackner & Anne R. Wondisford & Laurel N. Moneysmith & Alexander Hirschi & Sara Craig & Sahar A, 2024. "TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Gianfranco Matrone & Sung Yun Jung & Jong Min Choi & Antrix Jain & Hon-Chiu Eastwood Leung & Kimal Rajapakshe & Cristian Coarfa & Julie Rodor & Martin A. Denvir & Andrew H. Baker & John P. Cooke, 2021. "Nuclear S-nitrosylation impacts tissue regeneration in zebrafish," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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