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Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

Author

Listed:
  • Piotr Kazmierczak

    (The Scripps Research
    Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA)

  • Hirofumi Sakaguchi

    (Laboratory of Cellular Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Joshua Tokita

    (Laboratory of Cellular Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Elizabeth M. Wilson-Kubalek

    (The Scripps Research)

  • Ronald A. Milligan

    (The Scripps Research)

  • Ulrich Müller

    (The Scripps Research
    Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA)

  • Bechara Kachar

    (Laboratory of Cellular Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA)

Abstract

Tip-link structure revealed Hair cells of the inner ear are so-called because of the hair-like projections, or stereocilia, that protrude from their apical surface. Sound-induced stereocilial motion is thought to be coupled to mechanoelectrical transduction channels via the 'tip links' that connect stereocilia to one another. Kazmierczak et al. now report the composition of mammalian tip links. They are formed by the interaction of two members of the family of calcium-dependent cell adhesion proteins, cadherin and protocadherin 15. Interestingly, mutation of these cadherins causes deafness in humans and one such mutation disrupts the interaction between the two molecules.

Suggested Citation

  • Piotr Kazmierczak & Hirofumi Sakaguchi & Joshua Tokita & Elizabeth M. Wilson-Kubalek & Ronald A. Milligan & Ulrich Müller & Bechara Kachar, 2007. "Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells," Nature, Nature, vol. 449(7158), pages 87-91, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7158:d:10.1038_nature06091
    DOI: 10.1038/nature06091
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    Cited by:

    1. Maryna V. Ivanchenko & Daniel M. Hathaway & Alex J. Klein & Bifeng Pan & Olga Strelkova & Pedro De-la-Torre & Xudong Wu & Cole W. Peters & Eric M. Mulhall & Kevin T. Booth & Corey Goldstein & Joseph B, 2023. "Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Nisha Arora & Jagadish P. Hazra & Sandip Roy & Gaurav K. Bhati & Sarika Gupta & K. P. Yogendran & Abhishek Chaudhuri & Amin Sagar & Sabyasachi Rakshit, 2024. "Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Elliot Medina & Yathreb Easa & Daniel K. Lester & Eric K. Lau & David Sprinzak & Vincent C. Luca, 2023. "Structure of the planar cell polarity cadherins Fat4 and Dachsous1," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Jeong Han Lee & Maria C. Perez-Flores & Seojin Park & Hyo Jeong Kim & Yingying Chen & Mincheol Kang & Jennifer Kersigo & Jinsil Choi & Phung N. Thai & Ryan L. Woltz & Dolores Columba Perez-Flores & Gu, 2024. "The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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