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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

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  • Eros Lazzerini Denchi

    (Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA)

  • Titia de Lange

    (Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA)

Abstract

Double bluff The telomeres that cap normal chromosomes share virtually the same structure as damaged DNA sequences within chromosomes. So how do telomeres evade recognition by the DNA-repair machinery? Simple: two telomere binding proteins, TRF2 and POT1, block the activation of two key DNA damage response pathways. With TRF2 and POT1 inactivated, telomeres can be 'repaired' into the chromosomes where they don't belong.

Suggested Citation

  • Eros Lazzerini Denchi & Titia de Lange, 2007. "Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1," Nature, Nature, vol. 448(7157), pages 1068-1071, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7157:d:10.1038_nature06065
    DOI: 10.1038/nature06065
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    Cited by:

    1. Qadar Pasha & Manjari Rain & Sana Tasnim & Hema Kanipakam & Tashi Thinlas & Ghulam Mohammad, 2023. "The Telomere-Telomerase System Is Detrimental to Health at High-Altitude," IJERPH, MDPI, vol. 20(3), pages 1-22, January.

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