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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

Author

Listed:
  • Paul Krimpenfort

    (Division of Molecular Genetics and Centre for Biomedical Genetics,)

  • Annemieke IJpenberg

    (Division of Molecular Genetics and Centre for Biomedical Genetics,
    Present address: GSF, Institute for Stem Cell Research, D-85764 Munich, Germany.)

  • Ji-Ying Song

    (The Netherlands Cancer Institute)

  • Martin van der Valk

    (The Netherlands Cancer Institute)

  • Martijn Nawijn

    (Division of Molecular Genetics and Centre for Biomedical Genetics,)

  • John Zevenhoven

    (Division of Molecular Genetics and Centre for Biomedical Genetics,)

  • Anton Berns

    (Division of Molecular Genetics and Centre for Biomedical Genetics,)

Abstract

A locus on chromosome 9p21 which encodes three cell cycle inhibitors is frequently deleted in human cancer. Two of these, p16INKa and p14ARF, function as tumour suppressors. A new mouse model now shows that a third, p15INK4b, also contributes to the tumour suppressor function of this locus. Mice lacking all three show enhanced tumourigenesis and a broader tumour spectrum.

Suggested Citation

  • Paul Krimpenfort & Annemieke IJpenberg & Ji-Ying Song & Martin van der Valk & Martijn Nawijn & John Zevenhoven & Anton Berns, 2007. "p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a," Nature, Nature, vol. 448(7156), pages 943-946, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7156:d:10.1038_nature06084
    DOI: 10.1038/nature06084
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    Cited by:

    1. Takayoshi Sasako & Toshihiro Umehara & Kotaro Soeda & Kazuma Kaneko & Miho Suzuki & Naoki Kobayashi & Yukiko Okazaki & Miwa Tamura-Nakano & Tomoki Chiba & Domenico Accili & C. Ronald Kahn & Tetsuo Nod, 2022. "Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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