IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v448y2007i7156d10.1038_nature06072.html
   My bibliography  Save this article

The effects of molecular noise and size control on variability in the budding yeast cell cycle

Author

Listed:
  • Stefano Di Talia

    (The Rockefeller University
    Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA)

  • Jan M. Skotheim

    (Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA)

  • James M. Bean

    (The Rockefeller University
    Present address: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.)

  • Eric D. Siggia

    (Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA)

  • Frederick R. Cross

    (The Rockefeller University)

Abstract

Reports on single cell experiments in budding yeast that analyse the role of molecular noise during the G1 phase of the cell cycle. Variability in the timing of G1 can be attributed to variations in cell size at cell birth, as well as variations of a size-independent 'timer' step. These two steps are modular and together control the timing of the critical Start transition of the G1 phase.

Suggested Citation

  • Stefano Di Talia & Jan M. Skotheim & James M. Bean & Eric D. Siggia & Frederick R. Cross, 2007. "The effects of molecular noise and size control on variability in the budding yeast cell cycle," Nature, Nature, vol. 448(7156), pages 947-951, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7156:d:10.1038_nature06072
    DOI: 10.1038/nature06072
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06072
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06072?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Andreas Doncic & Umut Eser & Oguzhan Atay & Jan M Skotheim, 2013. "An Algorithm to Automate Yeast Segmentation and Tracking," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-11, March.
    2. Chengjun Cao & Keyi Wang & Yina Wang & Tong-Bao Liu & Amariliz Rivera & Chaoyang Xue, 2022. "Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Andreas P. Cuny & K. Tanuj Sapra & David Martinez-Martin & Gotthold Fläschner & Jonathan D. Adams & Sascha Martin & Christoph Gerber & Fabian Rudolf & Daniel J. Müller, 2022. "High-resolution mass measurements of single budding yeast reveal linear growth segments," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. G. Yahya & P. Menges & P. S. Amponsah & D. A. Ngandiri & D. Schulz & A. Wallek & N. Kulak & M. Mann & P. Cramer & V. Savage & M. Räschle & Z. Storchova, 2022. "Sublinear scaling of the cellular proteome with ploidy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Dola Sengupta & Sandip Kar, 2015. "Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately?," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-24, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:448:y:2007:i:7156:d:10.1038_nature06072. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.