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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Author

Listed:
  • Akinori Takaoka

    (and
    Institute for Genetic Medicine, Hokkaido University, and)

  • ZhiChao Wang

    (and)

  • Myoung Kwon Choi

    (and)

  • Hideyuki Yanai

    (and)

  • Hideo Negishi

    (and)

  • Tatsuma Ban

    (and)

  • Yan Lu

    (and)

  • Makoto Miyagishi

    (Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Tatsuhiko Kodama

    (Research Center for Advanced Science and Technology, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan)

  • Kenya Honda

    (and)

  • Yusuke Ohba

    (Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo 060-0815, Japan)

  • Tadatsugu Taniguchi

    (and)

Abstract

DNA and immunity DNA is a potent activator of immune responses. This has been known for more than 40 years, but the mechanism involved is still unclear. Now Takaoka et al. have identified a cytosolic DNA sensor that's involved in the innate immune response. The molecule is interferon-inducible protein DLM-1/ZBP1. No biological function had been found for this before, hence a renaming as DAI, (for DNA-dependent activator of IFN-regulatory factors). The identification of DAI as a key DNA sensor may offer new insight into the signalling mechanisms underlying DNA associated antimicrobial immunity and autoimmune disorders.

Suggested Citation

  • Akinori Takaoka & ZhiChao Wang & Myoung Kwon Choi & Hideyuki Yanai & Hideo Negishi & Tatsuma Ban & Yan Lu & Makoto Miyagishi & Tatsuhiko Kodama & Kenya Honda & Yusuke Ohba & Tadatsugu Taniguchi, 2007. "DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response," Nature, Nature, vol. 448(7152), pages 501-505, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7152:d:10.1038_nature06013
    DOI: 10.1038/nature06013
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    Cited by:

    1. Yan Jiang & Siqi Sun & Yuan Quan & Xin Wang & Yuling You & Xiao Zhang & Yue Zhang & Yin Liu & Bingjing Wang & Henan Xu & Xuetao Cao, 2023. "Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yongfang Lin & Jing Yang & Qili Yang & Sha Zeng & Jiayu Zhang & Yuanxiang Zhu & Yuxin Tong & Lin Li & Weiqi Tan & Dahua Chen & Qinmiao Sun, 2023. "PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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