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A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

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  • Hidde L. Ploegh

    (Whitehead Institute, Cambridge, Massachusetts 02142, USA)

Abstract

Ditch the 'dislocon'? A protein channel has been hypothesized as a component of the endoplasmic reticulum (ER) to account for the fact that misfolded proteins and non-enveloped viruses can pass through the ER into the cytoplasm. Der1 protein in yeast and the Derlins in other eukaryotes are examples of protein types that might function in such a dislocation channel or 'dislocon'. But Hidde Ploegh, writing in our occasional Hypothesis series, suggests an alternative mechanism that might do the job without the need for a protein-based channel. Instead, an escape hatch triggered by lipid rearrangement would allow both proteins and viruses to traverse the ER.

Suggested Citation

  • Hidde L. Ploegh, 2007. "A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum," Nature, Nature, vol. 448(7152), pages 435-438, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7152:d:10.1038_nature06004
    DOI: 10.1038/nature06004
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    Cited by:

    1. Patel, Alok & Pruthi, Vikas & Pruthi, Parul A., 2017. "Synchronized nutrient stress conditions trigger the diversion of CDP-DG pathway of phospholipids synthesis towards de novo TAG synthesis in oleaginous yeast escalating biodiesel production," Energy, Elsevier, vol. 139(C), pages 962-974.

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