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Variants conferring risk of atrial fibrillation on chromosome 4q25

Author

Listed:
  • Daniel F. Gudbjartsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • David O. Arnar

    (Landspitali University Hospital, 101 Reykjavik, Iceland)

  • Anna Helgadottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Solveig Gretarsdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Hilma Holm

    (Landspitali University Hospital, 101 Reykjavik, Iceland)

  • Asgeir Sigurdsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Adalbjorg Jonasdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Adam Baker

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Gudmar Thorleifsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Kristleifur Kristjansson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Arnar Palsson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Thorarinn Blondal

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Patrick Sulem

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Valgerdur M. Backman

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Gudmundur A. Hardarson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Ebba Palsdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Agnar Helgason

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Runa Sigurjonsdottir

    (Landspitali University Hospital, 101 Reykjavik, Iceland)

  • Jon T. Sverrisson

    (Akureyri Regional Hospital, 600 Akureyri, Iceland)

  • Konstantinos Kostulas

    (Karolinska Institutet at Karolinska University Hospital, Huddinge S-141 86, Sweden)

  • Maggie C. Y. Ng

    (Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong)

  • Larry Baum

    (Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong)

  • Wing Yee So

    (Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong)

  • Ka Sing Wong

    (Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong)

  • Juliana C. N. Chan

    (Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong)

  • Karen L. Furie

    (Department of Neurology,)

  • Steven M. Greenberg

    (Department of Neurology,)

  • Michelle Sale

    (Department of Neurology,)

  • Peter Kelly

    (Department of Neurology,)

  • Calum A. MacRae

    (Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Eric E. Smith

    (Department of Neurology,)

  • Jonathan Rosand

    (Department of Neurology,)

  • Jan Hillert

    (Karolinska Institutet at Karolinska University Hospital, Huddinge S-141 86, Sweden)

  • Ronald C. W. Ma

    (Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong)

  • Patrick T. Ellinor

    (Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Gudmundur Thorgeirsson

    (Landspitali University Hospital, 101 Reykjavik, Iceland)

  • Jeffrey R. Gulcher

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Augustine Kong

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Unnur Thorsteinsdottir

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

  • Kari Stefansson

    (deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland)

Abstract

Take heart A genome-wide association scan in populations from Sweden, North America and China has identified two single-letter sequence variants on chromosome 4q25 as risk factors for atrial fibrillation, the most common form of cardiac arrhythmia. Both are adjacent to the PITX2 gene, known to be involved in early heart development. This work identifies PITX2 as a target for diagnostic tests and possibly for therapeutic intervention.

Suggested Citation

  • Daniel F. Gudbjartsson & David O. Arnar & Anna Helgadottir & Solveig Gretarsdottir & Hilma Holm & Asgeir Sigurdsson & Adalbjorg Jonasdottir & Adam Baker & Gudmar Thorleifsson & Kristleifur Kristjansso, 2007. "Variants conferring risk of atrial fibrillation on chromosome 4q25," Nature, Nature, vol. 448(7151), pages 353-357, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7151:d:10.1038_nature06007
    DOI: 10.1038/nature06007
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    Cited by:

    1. Manon Baudic & Hiroshige Murata & Fernanda M. Bosada & Uirá Souto Melo & Takanori Aizawa & Pierre Lindenbaum & Lieve E. Maarel & Amaury Guedon & Estelle Baron & Enora Fremy & Adrien Foucal & Taisuke I, 2024. "TAD boundary deletion causes PITX2-related cardiac electrical and structural defects," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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