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Two distinct modes of guidance signalling during collective migration of border cells

Author

Listed:
  • Ambra Bianco

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany)

  • Minna Poukkula

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany)

  • Adam Cliffe

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Temasek Life Sciences Laboratory (TLL), 1 Research Link, National University of Singapore, Singapore 117604)

  • Juliette Mathieu

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany)

  • Carlos M. Luque

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Present addresses: Centro Andaluz de Biología del Desarrollo CSIC/UPO, Carretera de Utrera, Km. 1, 41013 Sevilla, Spain (C.M.L.); Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 02115 Boston, USA (T.A.F.).)

  • Tudor A. Fulga

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Present addresses: Centro Andaluz de Biología del Desarrollo CSIC/UPO, Carretera de Utrera, Km. 1, 41013 Sevilla, Spain (C.M.L.); Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 02115 Boston, USA (T.A.F.).)

  • Pernille Rørth

    (European Molecular Biology Laboratory, Heidelberg, 69117, Germany
    Temasek Life Sciences Laboratory (TLL), 1 Research Link, National University of Singapore, Singapore 117604)

Abstract

Cell migration The movement of groups of cells during development and tumour metastasis is poorly understood. A handle on the process is provided by border cell migration in the Drosophila ovary, a powerful model for the regulation of cell migration and guidance in vivo. Using Drosophila's sophisticated genetics, and innovative live imaging, Bianco et al. show that border cells migrate in two phases. First, cells migrate posteriorly in a fast mode. For the second half of posterior migration, and for dorsal migration, border cells move slowly as a compact cluster and cells begin to shuffle within clusters. The two migration modes have quite distinct sensitivities to receptor tyrosine kinase signalling pathways and the cell cluster processes information as a group, making use of the difference in signalling levels between individual cells.

Suggested Citation

  • Ambra Bianco & Minna Poukkula & Adam Cliffe & Juliette Mathieu & Carlos M. Luque & Tudor A. Fulga & Pernille Rørth, 2007. "Two distinct modes of guidance signalling during collective migration of border cells," Nature, Nature, vol. 448(7151), pages 362-365, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7151:d:10.1038_nature05965
    DOI: 10.1038/nature05965
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    Cited by:

    1. Zhaowei Meng & Shanshan Lou & Jian Tan & Qiang Jia & Rongxiu Zheng & Geli Liu & Mei Zhu & Qing He & Dong Li, 2014. "Scintigraphic Detection of Dual Ectopic Thyroid Tissue: Experience of a Chinese Tertiary Hospital," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-6, April.
    2. Sijia Zhou & Peng Li & Jiaying Liu & Juan Liao & Hao Li & Lin Chen & Zhihua Li & Qiongyu Guo & Karine Belguise & Bin Yi & Xiaobo Wang, 2022. "Two Rac1 pools integrate the direction and coordination of collective cell migration," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Néstor Sepúlveda & Laurence Petitjean & Olivier Cochet & Erwan Grasland-Mongrain & Pascal Silberzan & Vincent Hakim, 2013. "Collective Cell Motion in an Epithelial Sheet Can Be Quantitatively Described by a Stochastic Interacting Particle Model," PLOS Computational Biology, Public Library of Science, vol. 9(3), pages 1-12, March.

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