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Intronic microRNA precursors that bypass Drosha processing

Author

Listed:
  • J. Graham Ruby

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Calvin H. Jan

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • David P. Bartel

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

Abstract

MicroRNAs (miRNAs) are produced through a set of cleavages within a longer RNA, one of the nucleases involved in this process is Drosha. A subset of miRNAs (mirtrons) are matured through an alternative pathway that is Drosha-independent. These mirtrons may be the early ancestors of the majority of miRNAs that were expressed once Drosha function emerged.

Suggested Citation

  • J. Graham Ruby & Calvin H. Jan & David P. Bartel, 2007. "Intronic microRNA precursors that bypass Drosha processing," Nature, Nature, vol. 448(7149), pages 83-86, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7149:d:10.1038_nature05983
    DOI: 10.1038/nature05983
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    Cited by:

    1. Chengyun Wu & Xingsong Wang & Yan Li & Weibo Zhen & Chunfei Wang & Xiaoqing Wang & Zhouli Xie & Xiumei Xu & Siyi Guo & José Ramón Botella & Binglian Zheng & Wei Wang & Chun-Peng Song & Zhubing Hu, 2024. "Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Shuangmei Tian & Ziyu Zhao & Beibei Ren & Degeng Wang, 2024. "Non-Linear Relationship between MiRNA Regulatory Activity and Binding Site Counts on Target mRNAs," Data, MDPI, vol. 9(10), pages 1-13, September.

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