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Base-excision repair of oxidative DNA damage

Author

Listed:
  • Sheila S. David

    (University of California at Davis)

  • Valerie L. O'Shea

    (University of Utah)

  • Sucharita Kundu

    (University of Utah)

Abstract

Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.

Suggested Citation

  • Sheila S. David & Valerie L. O'Shea & Sucharita Kundu, 2007. "Base-excision repair of oxidative DNA damage," Nature, Nature, vol. 447(7147), pages 941-950, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7147:d:10.1038_nature05978
    DOI: 10.1038/nature05978
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    Cited by:

    1. Lin Xiao & Liang-Liang Wang & Chao-Qun Wu & Han Li & Qiu-Long Zhang & Yang Wang & Liang Xu, 2022. "Controllable DNA hybridization by host–guest complexation-mediated ligand invasion," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Yangyang Ding & Xiang Gui & Xiang Chu & Yueyue Sun & Sixuan Zhang & Huan Tong & Wen Ju & Yue Li & Zengtian Sun & Mengdi Xu & Zhenyu Li & Robert K. Andrews & Elizabeth E. Gardiner & Lingyu Zeng & Kaili, 2023. "MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Nisha Tapryal & Anirban Chakraborty & Kaushik Saha & Azharul Islam & Lang Pan & Koa Hosoki & Ibrahim M. Sayed & Jason M. Duran & Joshua Alcantara & Vanessa Castillo & Courtney Tindle & Altaf H. Sarker, 2023. "The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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