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Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

Author

Listed:
  • Trista E. North

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Wolfram Goessling

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Carl R. Walkley

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Claudia Lengerke

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Kamden R. Kopani

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Allegra M. Lord

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Gerhard J. Weber

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Teresa V. Bowman

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

  • Il-Ho Jang

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Tilo Grosser

    (Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • Garret A. FitzGerald

    (Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

  • George Q. Daley

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Stuart H. Orkin

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Leonard I. Zon

    (Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

Abstract

A tonic to the blood A previously unidentified modulator of vertebrate haematopoietic stem cell (HSC) number has been discovered using a chemical genetic screen in zebrafish. Prostaglandin E2 (PGE2) increases HSCs in the embryo and enhances marrow recovery following irradiation of adult fish. These effects of PGE2 on stem and progenitor cell number are conserved across vertebrate species. This suggests that modulation of this pathway could be used to treat patients undergoing bone marrow transplant and for some forms of anaemia.

Suggested Citation

  • Trista E. North & Wolfram Goessling & Carl R. Walkley & Claudia Lengerke & Kamden R. Kopani & Allegra M. Lord & Gerhard J. Weber & Teresa V. Bowman & Il-Ho Jang & Tilo Grosser & Garret A. FitzGerald &, 2007. "Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis," Nature, Nature, vol. 447(7147), pages 1007-1011, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7147:d:10.1038_nature05883
    DOI: 10.1038/nature05883
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    Cited by:

    1. Trent D. Hall & Hyunjin Kim & Mahmoud Dabbah & Jacquelyn A. Myers & Jeremy Chase Crawford & Antonio Morales-Hernandez & Claire E. Caprio & Pramika Sriram & Emilia Kooienga & Marta Derecka & Esther A. , 2022. "Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Xiaoyi Cheng & Radwa Barakat & Giulia Pavani & Masuma Khatun Usha & Rodolfo Calderon & Elizabeth Snella & Abigail Gorden & Yudi Zhang & Paul Gadue & Deborah L. French & Karin S. Dorman & Antonella Fid, 2023. "Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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