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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Author

Listed:
  • Derrick J. Rossi

    (and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA)

  • David Bryder

    (and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Present address: Lund University, Institute for Experimental Medical Science, BMC I13, 22184, Lund, Sweden.)

  • Jun Seita

    (and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA)

  • Andre Nussenzweig

    (Experimental Immunology Branch and Laboratory for Receptor Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Jan Hoeijmakers

    (Erasmus Medical Center, PO Box 1738, 3000DR, Rotterdam, The Netherlands)

  • Irving L. Weissman

    (and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA)

Abstract

DNA damage does not significantly impact in the establishment, maintenance or expansion of long-term reconstituting haematopoietic stem cells (LT-HSC), it is instead a physiological mechanism of stem cell ageing that may underlie the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury.

Suggested Citation

  • Derrick J. Rossi & David Bryder & Jun Seita & Andre Nussenzweig & Jan Hoeijmakers & Irving L. Weissman, 2007. "Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age," Nature, Nature, vol. 447(7145), pages 725-729, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7145:d:10.1038_nature05862
    DOI: 10.1038/nature05862
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    Cited by:

    1. Robert Snyder, 2012. "Leukemia and Benzene," IJERPH, MDPI, vol. 9(8), pages 1-19, August.
    2. Hans B Sieburg & Giulio Cattarossi & Christa E Muller-Sieburg, 2013. "Lifespan Differences in Hematopoietic Stem Cells are Due to Imperfect Repair and Unstable Mean-Reversion," PLOS Computational Biology, Public Library of Science, vol. 9(4), pages 1-15, April.

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