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Two neurons mediate diet-restriction-induced longevity in C. elegans

Author

Listed:
  • Nicholas A. Bishop

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Leonard Guarente

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

Abstract

Dietary restriction extends lifespan and retards age-related disease in many species and profoundly alters endocrine function in mammals. However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated. Here we show that increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head. Dietary restriction activates skn-1 in these two neurons, which signals peripheral tissues to increase metabolic activity. These findings demonstrate that increased lifespan in a diet-restricted metazoan depends on cell non-autonomous signalling from central neuronal cells to non-neuronal body tissues, and suggest that the ASI neurons mediate diet-restriction-induced longevity by an endocrine mechanism.

Suggested Citation

  • Nicholas A. Bishop & Leonard Guarente, 2007. "Two neurons mediate diet-restriction-induced longevity in C. elegans," Nature, Nature, vol. 447(7144), pages 545-549, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7144:d:10.1038_nature05904
    DOI: 10.1038/nature05904
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    Cited by:

    1. Hillary A. Miller & Shijiao Huang & Elizabeth S. Dean & Megan L. Schaller & Angela M. Tuckowski & Allyson S. Munneke & Safa Beydoun & Scott D. Pletcher & Scott F. Leiser, 2022. "Serotonin and dopamine modulate aging in response to food odor and availability," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Ivan Gusarov & Ilya Shamovsky & Bibhusita Pani & Laurent Gautier & Svetlana Eremina & Olga Katkova-Zhukotskaya & Alexander Mironov & Alexander А. Makarov & Evgeny Nudler, 2021. "Dietary thiols accelerate aging of C. elegans," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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