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The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

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  • Mamta Tahiliani

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
    Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Pinchao Mei

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue)

  • Rui Fang

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue)

  • Thiago Leonor

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue)

  • Michael Rutenberg

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue
    University of Florida College of Medicine, Gainesville, Florida 32610, USA)

  • Fumiko Shimizu

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue)

  • Jing Li

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue)

  • Anjana Rao

    (Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Yujiang Shi

    (Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue)

Abstract

Mental retardation link A protein previously implicated in X-linked mental retardation has now been found to influence gene expression by modifying histones. The JmjC-domain-containing protein SMCX (or JARID1C) is a histone demethylase that demethylates H3 trimethylated at lysine 4, both in vitro and in cells, and can repress transcription of certain neuronal genes. The finding suggests that mutations in SMCX might contribute to disease by impairing regulation of neuronal genes via this effect on chromatin.

Suggested Citation

  • Mamta Tahiliani & Pinchao Mei & Rui Fang & Thiago Leonor & Michael Rutenberg & Fumiko Shimizu & Jing Li & Anjana Rao & Yujiang Shi, 2007. "The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation," Nature, Nature, vol. 447(7144), pages 601-605, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7144:d:10.1038_nature05823
    DOI: 10.1038/nature05823
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    Cited by:

    1. Milan Kumar Samanta & Srimonta Gayen & Clair Harris & Emily Maclary & Yumie Murata-Nakamura & Rebecca M. Malcore & Robert S. Porter & Patricia M. Garay & Christina N. Vallianatos & Paul B. Samollow & , 2022. "Activation of Xist by an evolutionarily conserved function of KDM5C demethylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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