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Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

Author

Listed:
  • Chang Liu

    (Life Sciences Institute and Department of Cell & Developmental Biology)

  • Siming Li

    (Life Sciences Institute and Department of Cell & Developmental Biology)

  • Tiecheng Liu

    (University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA)

  • Jimo Borjigin

    (University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA)

  • Jiandie D. Lin

    (Life Sciences Institute and Department of Cell & Developmental Biology)

Abstract

Clocking on Many physiological parameters, such as body temperature, blood glucose and heart rate, undergo cyclic changes with the 24-hour rhythms of the circadian clock. It has been a mystery how the metabolic pathways are coupled to the clockwork, but now experiments in mice suggest that the metabolic transcriptional regulator PGC-1α is a key factor. Mice lacking PGC-1α display abnormal diurnal rhythms of activity, body temperature and metabolic rate. At the mechanistic level, PGC-1α regulates clock gene expression through coactivation of the ROR family of orphan nuclear receptors.

Suggested Citation

  • Chang Liu & Siming Li & Tiecheng Liu & Jimo Borjigin & Jiandie D. Lin, 2007. "Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism," Nature, Nature, vol. 447(7143), pages 477-481, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7143:d:10.1038_nature05767
    DOI: 10.1038/nature05767
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    Cited by:

    1. Dalia Halawani & Yiqun Wang & Aarthi Ramakrishnan & Molly Estill & Xijing He & Li Shen & Roland H. Friedel & Hongyan Zou, 2023. "Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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