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RNA-templated DNA repair

Author

Listed:
  • Francesca Storici

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA)

  • Katarzyna Bebenek

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA)

  • Thomas A. Kunkel

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA)

  • Dmitry A. Gordenin

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA)

  • Michael A. Resnick

    (Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, North Carolina 27709, USA)

Abstract

Although RNA is used to synthesize DNA by specialized enzymes such as reverse transcriptase and telomerase, it has never been shown to be used directly in DNA repair. Here Resnick and colleagues find that short RNA oligonucleotides which are complementary to the sequences at a DNA double-strand break can serve as a template for repair by the normal replicative DNA polymerases, suggesting that information contained in an RNA molecule could be transferred into the genome.

Suggested Citation

  • Francesca Storici & Katarzyna Bebenek & Thomas A. Kunkel & Dmitry A. Gordenin & Michael A. Resnick, 2007. "RNA-templated DNA repair," Nature, Nature, vol. 447(7142), pages 338-341, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7142:d:10.1038_nature05720
    DOI: 10.1038/nature05720
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    Cited by:

    1. Dayana E. Salas-Leiva & Eelco C. Tromer & Bruce A. Curtis & Jon Jerlström-Hultqvist & Martin Kolisko & Zhenzhen Yi & Joan S. Salas-Leiva & Lucie Gallot-Lavallée & Shelby K. Williams & Geert J. P. L. K, 2021. "Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Guangxue Liu & Jimin Li & Boxue He & Jiaqi Yan & Jingyu Zhao & Xuejie Wang & Xiaocong Zhao & Jingyan Xu & Yeyao Wu & Simin Zhang & Xiaoli Gan & Chun Zhou & Xiangpan Li & Xinghua Zhang & Xuefeng Chen, 2023. "Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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