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The human RNA kinase hClp1 is active on 3′ transfer RNA exons and short interfering RNAs

Author

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  • Stefan Weitzer

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 3, A-1030 Vienna, Austria)

  • Javier Martinez

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 3, A-1030 Vienna, Austria)

Abstract

During tRNA splicing, the 5' end of the 3' exon must be phosphorylated for subsequent ligation of the two exons to occur. The kinase which performs this reaction, human Clp1, is identified, is also able to phosphorylate exogenously introduced siRNAs.

Suggested Citation

  • Stefan Weitzer & Javier Martinez, 2007. "The human RNA kinase hClp1 is active on 3′ transfer RNA exons and short interfering RNAs," Nature, Nature, vol. 447(7141), pages 222-226, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7141:d:10.1038_nature05777
    DOI: 10.1038/nature05777
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    Cited by:

    1. Yizhi Yuan & Florian M. Stumpf & Lisa A. Schlor & Olivia P. Schmidt & Philip Saumer & Luisa B. Huber & Matthias Frese & Eva Höllmüller & Martin Scheffner & Florian Stengel & Kay Diederichs & Andreas M, 2023. "Chemoproteomic discovery of a human RNA ligase," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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