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Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Author

Listed:
  • Christopher N. Scanlan

    (Glycobiology Institute, University of Oxford)

  • John Offer

    (Scripps Oxford Laboratory, University of Oxford)

  • Nicole Zitzmann

    (Glycobiology Institute, University of Oxford)

  • Raymond A. Dwek

    (Glycobiology Institute, University of Oxford)

Abstract

The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.

Suggested Citation

  • Christopher N. Scanlan & John Offer & Nicole Zitzmann & Raymond A. Dwek, 2007. "Exploiting the defensive sugars of HIV-1 for drug and vaccine design," Nature, Nature, vol. 446(7139), pages 1038-1045, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05818
    DOI: 10.1038/nature05818
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    Cited by:

    1. Wayne Delport & Konrad Scheffler & Cathal Seoighe, 2008. "Frequent Toggling between Alternative Amino Acids Is Driven by Selection in HIV-1," PLOS Pathogens, Public Library of Science, vol. 4(12), pages 1-13, December.
    2. Yi-Nan Zhang & Jennifer Paynter & Aleksandar Antanasijevic & Joel D. Allen & Mor Eldad & Yi-Zong Lee & Jeffrey Copps & Maddy L. Newby & Linling He & Deborah Chavez & Pat Frost & Anna Goodroe & John Du, 2023. "Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates," Nature Communications, Nature, vol. 14(1), pages 1-29, December.

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