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Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

Author

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  • Igor M. Samokhvalov

    (Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650-0047, Japan)

  • Natalia I. Samokhvalova

    (Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650-0047, Japan)

  • Shin-ichi Nishikawa

    (Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN Kobe, Kobe 650-0047, Japan)

Abstract

The first haematopoietic stem cells (HSCs) appear in the aorta-gonad-mesonephros (AGM) region, major vitelline and umbilical vessels, and placenta; however, whether they arise locally or from immigrant yolk sac precursor cells remains unclear. This issue is best addressed by measuring cell-lineage relationships rather than cell potentials. To undertake long-term in vivo tracing of yolk sac cells, we designed a non-invasive pulse-labelling system based on Cre/loxP recombination. Here we show that in Runx1+/- (runt-related transcription factor 1) heterozygous mice, yolk sac cells expressing Runx1 at embryonic day 7.5 develop into fetal lymphoid progenitors and adult HSCs. During mid-gestation the labelled (embryonic day 7.5) yolk sac cells colonize the umbilical cord, the AGM region and subsequently the embryonic liver. This raises the possibility that some HSCs associated with major embryonic vasculature are derived from yolk sac precursors. We observed virtually no contribution of the labelled cells towards the yolk sac vasculature, indicating early segregation of endothelial and haematopoietic lineages.

Suggested Citation

  • Igor M. Samokhvalov & Natalia I. Samokhvalova & Shin-ichi Nishikawa, 2007. "Cell tracing shows the contribution of the yolk sac to adult haematopoiesis," Nature, Nature, vol. 446(7139), pages 1056-1061, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05725
    DOI: 10.1038/nature05725
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    Cited by:

    1. Anna E. Williamson & Sanuri Liyanage & Mohammadhossein Hassanshahi & Malathi S. I. Dona & Deborah Toledo-Flores & Dang X. A. Tran & Catherine Dimasi & Nisha Schwarz & Sanuja Fernando & Thalia Salagara, 2024. "Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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