IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v446y2007i7139d10.1038_nature05704.html
   My bibliography  Save this article

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Author

Listed:
  • Schuichi Koizumi

    (National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan
    Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3893, Japan)

  • Yukari Shigemoto-Mogami

    (National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan)

  • Kaoru Nasu-Tada

    (National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan)

  • Yoichi Shinozaki

    (National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka 812-8582, Japan)

  • Keiko Ohsawa

    (National Institute of Neuroscience, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan)

  • Makoto Tsuda

    (Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka 812-8582, Japan)

  • Bhalchandra V. Joshi

    (Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA)

  • Kenneth A. Jacobson

    (Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA)

  • Shinichi Kohsaka

    (National Institute of Neuroscience, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan)

  • Kazuhide Inoue

    (Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka 812-8582, Japan)

Abstract

Keeping things tidy Phagocytosis is thought to be initiated by activation of phagocytosis-promoting receptors that recognize 'eat-me' signals such as phosphatidylserine or amyloid-β expressed in the apoptotic cells. But now Koizumi et al. demonstrate a novel type of microglial phagocytosis that requires neither typical 'eat-me' signals nor Fc receptor ligands for initiation. Instead, this phagocytosis is promoted by the diffusible extracellular molecule uridine 5′-diphosphate, released by injured cells. The UDP activates P2Y6 receptors on the microglial surface. The clearance of dead cells is crucial to the maintenance of brain function, so these findings may have implications for a range of central nervous system diseases.

Suggested Citation

  • Schuichi Koizumi & Yukari Shigemoto-Mogami & Kaoru Nasu-Tada & Yoichi Shinozaki & Keiko Ohsawa & Makoto Tsuda & Bhalchandra V. Joshi & Kenneth A. Jacobson & Shinichi Kohsaka & Kazuhide Inoue, 2007. "UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis," Nature, Nature, vol. 446(7139), pages 1091-1095, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05704
    DOI: 10.1038/nature05704
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05704
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05704?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Andrew D. Kraft & G. Jean Harry, 2011. "Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity," IJERPH, MDPI, vol. 8(7), pages 1-39, July.
    2. Fangying Zhao & Jiangyong He & Jun Tang & Nianfei Cui & Yanyan Shi & Zhifan Li & Shengnan Liu & Yazhou Wang & Ming Ma & Congjian Zhao & Lingfei Luo & Li Li, 2022. "Brain milieu induces early microglial maturation through the BAX-Notch axis," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05704. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.