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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Author

Listed:
  • Michaela U. Gack

    (New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA
    Institute for Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany)

  • Young C. Shin

    (New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA)

  • Chul-Hyun Joo

    (New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA
    University of Ulsan College of Medicine, Seoul 138-736, South Korea)

  • Tomohiko Urano

    (Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan
    Research Center for Genomic Medicine, Saitama Medical School, Saitama 350-124-2, Japan)

  • Chengyu Liang

    (New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA)

  • Lijun Sun

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA)

  • Osamu Takeuchi

    (Japan Science and Technology Agency, Osaka 565-0871, Japan)

  • Shizuo Akira

    (Japan Science and Technology Agency, Osaka 565-0871, Japan)

  • Zhijian Chen

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA)

  • Satoshi Inoue

    (Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan
    Research Center for Genomic Medicine, Saitama Medical School, Saitama 350-124-2, Japan)

  • Jae U. Jung

    (New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, Massachusetts 01772, USA)

Abstract

The cytoplasmic receptor RIG-I recognizes viral RNAs and initiates a protective innate immune response against a number of important viruses. Here, it is shown that RIG-I is regulated by ubiquitination.

Suggested Citation

  • Michaela U. Gack & Young C. Shin & Chul-Hyun Joo & Tomohiko Urano & Chengyu Liang & Lijun Sun & Osamu Takeuchi & Shizuo Akira & Zhijian Chen & Satoshi Inoue & Jae U. Jung, 2007. "TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity," Nature, Nature, vol. 446(7138), pages 916-920, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7138:d:10.1038_nature05732
    DOI: 10.1038/nature05732
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    Cited by:

    1. Bryan Korithoski & Oralia Kolaczkowski & Krishanu Mukherjee & Reema Kola & Chandra Earl & Bryan Kolaczkowski, 2015. "Evolution of a Novel Antiviral Immune-Signaling Interaction by Partial-Gene Duplication," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-26, September.

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