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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

Author

Listed:
  • Sean R. Collins

    (Department of Cellular and Molecular Pharmacology,
    The California Institute for Quantitative Biomedical Research, and,
    Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA)

  • Kyle M. Miller

    (Cancer Research Institute, University of California, San Francisco, California 94115, USA)

  • Nancy L. Maas

    (Cancer Research Institute, University of California, San Francisco, California 94115, USA)

  • Assen Roguev

    (Department of Cellular and Molecular Pharmacology,
    The California Institute for Quantitative Biomedical Research, and,)

  • Jeffrey Fillingham

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Clement S. Chu

    (Department of Cellular and Molecular Pharmacology,
    The California Institute for Quantitative Biomedical Research, and,
    Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA)

  • Maya Schuldiner

    (Department of Cellular and Molecular Pharmacology,
    The California Institute for Quantitative Biomedical Research, and,
    Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA)

  • Marinella Gebbia

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Judith Recht

    (Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA)

  • Michael Shales

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Huiming Ding

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Hong Xu

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Junhong Han

    (Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA)

  • Kristin Ingvarsdottir

    (Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA)

  • Benjamin Cheng

    (Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada)

  • Brenda Andrews

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Charles Boone

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Shelley L. Berger

    (Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA)

  • Phil Hieter

    (Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada)

  • Zhiguo Zhang

    (Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA)

  • Grant W. Brown

    (University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • C. James Ingles

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Andrew Emili

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • C. David Allis

    (Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA)

  • David P. Toczyski

    (Cancer Research Institute, University of California, San Francisco, California 94115, USA)

  • Jonathan S. Weissman

    (Department of Cellular and Molecular Pharmacology,
    The California Institute for Quantitative Biomedical Research, and,
    Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA)

  • Jack F. Greenblatt

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Nevan J. Krogan

    (Department of Cellular and Molecular Pharmacology,
    The California Institute for Quantitative Biomedical Research, and,)

Abstract

An epistatic miniarray profile allows identification of multiprotein complexes involved in various aspects of chromosome biology. In one pathway, the histone acetyltransferase Rtt109 is found to modify histone H3 lysine 56 during DNA replication.

Suggested Citation

  • Sean R. Collins & Kyle M. Miller & Nancy L. Maas & Assen Roguev & Jeffrey Fillingham & Clement S. Chu & Maya Schuldiner & Marinella Gebbia & Judith Recht & Michael Shales & Huiming Ding & Hong Xu & Ju, 2007. "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map," Nature, Nature, vol. 446(7137), pages 806-810, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7137:d:10.1038_nature05649
    DOI: 10.1038/nature05649
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    Cited by:

    1. Sahiti Kuppa & Jaigeeth Deveryshetty & Rahul Chadda & Jenna R. Mattice & Nilisha Pokhrel & Vikas Kaushik & Angela Patterson & Nalini Dhingra & Sushil Pangeni & Marisa K. Sadauskas & Sajad Shiekh & Ham, 2022. "Rtt105 regulates RPA function by configurationally stapling the flexible domains," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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