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Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

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  • Fumiaki Ohtake

    (ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Atsushi Baba

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Ichiro Takada

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Maiko Okada

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Kei Iwasaki

    (ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan)

  • Hiromi Miki

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Sayuri Takahashi

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Japan)

  • Alexander Kouzmenko

    (ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Keiko Nohara

    (National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan)

  • Tomoki Chiba

    (Graduate School of Life and Environmental Sciences, and,)

  • Yoshiaki Fujii-Kuriyama

    (TARA Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8577, Japan
    SORST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan)

  • Shigeaki Kato

    (ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

Abstract

Dioxin toxicity The dioxins, a family of halogenated organic compounds formed as by-products of various industrial processes, are toxic because of their interaction with signalling pathways linked to steroid hormone function. A possible mechanism for this toxicity has now been found: dioxins form atypical ubiquitin ligases that mark out members of the nuclear steroid receptor family of gene transcription factors for untimely degradation.

Suggested Citation

  • Fumiaki Ohtake & Atsushi Baba & Ichiro Takada & Maiko Okada & Kei Iwasaki & Hiromi Miki & Sayuri Takahashi & Alexander Kouzmenko & Keiko Nohara & Tomoki Chiba & Yoshiaki Fujii-Kuriyama & Shigeaki Kato, 2007. "Dioxin receptor is a ligand-dependent E3 ubiquitin ligase," Nature, Nature, vol. 446(7135), pages 562-566, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7135:d:10.1038_nature05683
    DOI: 10.1038/nature05683
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    Cited by:

    1. Zikun Ma & Zhiyong Li & Yize Mao & Jingwei Ye & Zefu Liu & Yuzhao Wang & Chen Wei & Jun Cui & Zhuowei Liu & Xiaoyu Liang, 2023. "AhR diminishes the efficacy of chemotherapy via suppressing STING dependent type-I interferon in bladder cancer," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Donghong Zhang & Jinfeng Ning & Tharmarajan Ramprasath & Changjiang Yu & Xiaoxu Zheng & Ping Song & Zhonglin Xie & Ming-Hui Zou, 2022. "Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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