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Strain-resolved community proteomics reveals recombining genomes of acidophilic bacteria

Author

Listed:
  • Ian Lo

    (University of California, Berkeley, California 94720, USA)

  • Vincent J. Denef

    (University of California, Berkeley, California 94720, USA)

  • Nathan C. VerBerkmoes

    (Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA)

  • Manesh B. Shah

    (Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA)

  • Daniela Goltsman

    (University of California, Berkeley, California 94720, USA)

  • Genevieve DiBartolo

    (University of California, Berkeley, California 94720, USA)

  • Gene W. Tyson

    (University of California, Berkeley, California 94720, USA)

  • Eric E. Allen

    (University of California, Berkeley, California 94720, USA)

  • Rachna J. Ram

    (University of California, Berkeley, California 94720, USA)

  • J. Chris Detter

    (Joint Genome Institute, Walnut Creek, California 94598, USA)

  • Paul Richardson

    (Joint Genome Institute, Walnut Creek, California 94598, USA)

  • Michael P. Thelen

    (Lawrence Livermore National Laboratory, Livermore, California 94550, USA)

  • Robert L. Hettich

    (Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA)

  • Jillian F. Banfield

    (University of California, Berkeley, California 94720, USA)

Abstract

Mine of information Acid mine drainage formation, a widespread and serious environmental problem, is mediated by microbial consortia, often dominated by Leptospirillum group II. These organisms grow in sulphuric acid solutions with pH typically below 1.0, and highly enriched in toxic metals. Biofilms from the abandoned Richmond Mine in Iron Mountain, California, are ideal for the study of these microbial communities since they contain relatively few species. A high-resolution proteogenomic study suggests that the exchange of large blocks of gene variants between closely related bacterial populations and between individual organisms is crucial to their adaptation to this harsh ecological niche. This work is a significant advance in the study of microbial populations in their natural environments, and this proteo genomic approach should find application elsewhere, for instance in strain typing of pathogens.

Suggested Citation

  • Ian Lo & Vincent J. Denef & Nathan C. VerBerkmoes & Manesh B. Shah & Daniela Goltsman & Genevieve DiBartolo & Gene W. Tyson & Eric E. Allen & Rachna J. Ram & J. Chris Detter & Paul Richardson & Michae, 2007. "Strain-resolved community proteomics reveals recombining genomes of acidophilic bacteria," Nature, Nature, vol. 446(7135), pages 537-541, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7135:d:10.1038_nature05624
    DOI: 10.1038/nature05624
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    Cited by:

    1. Susanne Krause & Sabrina Gfrerer & Andriko Kügelgen & Carsten Reuse & Nina Dombrowski & Laura Villanueva & Boyke Bunk & Cathrin Spröer & Thomas R. Neu & Ute Kuhlicke & Kerstin Schmidt-Hohagen & Karste, 2022. "The importance of biofilm formation for cultivation of a Micrarchaeon and its interactions with its Thermoplasmatales host," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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