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A single type of progenitor cell maintains normal epidermis

Author

Listed:
  • Elizabeth Clayton

    (MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK)

  • David P. Doupé

    (MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK)

  • Allon M. Klein

    (Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK)

  • Douglas J. Winton

    (Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Benjamin D. Simons

    (Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK)

  • Philip H. Jones

    (MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK)

Abstract

Skin renewal gets simpler For more than 30 years, the accepted model of epithelial homeostasis has assumed that skin tissue is maintained by two separate populations of progenitor cells. Self-renewing stem cells were thought to give rise to short-lived progenitors that in turn form the new epidermis. Clayton et al. now suggest that this hypothesis can be replaced with a simpler model in which a single type of progenitor cell undergoes asymmetric division at a rate that ensures epidermal homeostasis.

Suggested Citation

  • Elizabeth Clayton & David P. Doupé & Allon M. Klein & Douglas J. Winton & Benjamin D. Simons & Philip H. Jones, 2007. "A single type of progenitor cell maintains normal epidermis," Nature, Nature, vol. 446(7132), pages 185-189, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7132:d:10.1038_nature05574
    DOI: 10.1038/nature05574
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    Cited by:

    1. Elle Koren & Alona Feldman & Marianna Yusupova & Avihay Kadosh & Egor Sedov & Roi Ankawa & Yahav Yosefzon & Waseem Nasser & Stefanie Gerstberger & Liam B. Kimel & Noa Priselac & Samara Brown & Sam Sha, 2022. "Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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