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The molecular organization of cypovirus polyhedra

Author

Listed:
  • Fasséli Coulibaly

    (School of Biological Sciences, University of Auckland, 1010, New Zealand)

  • Elaine Chiu

    (School of Biological Sciences, University of Auckland, 1010, New Zealand)

  • Keiko Ikeda

    (Protein Crystal Corporation, Osaka 541-0053, Japan)

  • Sascha Gutmann

    (Swiss Light Source at Paul Scherrer Institute, Villigen 5232, Switzerland)

  • Peter W. Haebel

    (Altana Pharma AG, Konstanz 78467, Germany)

  • Clemens Schulze-Briese

    (Swiss Light Source at Paul Scherrer Institute, Villigen 5232, Switzerland)

  • Hajime Mori

    (Kyoto Institute of Technology, Kyoto 606-8585, Japan)

  • Peter Metcalf

    (School of Biological Sciences, University of Auckland, 1010, New Zealand)

Abstract

Tough cubes Insect viruses that produce infectious polyhedra — crystals encapsulating thousands of virus particles — are widespread and important. The polyhedra microcrystals are remarkably stable, which can cause disease persistence, threatening silkworm cocoon harvests for instance. The molecular structure of one of these crystals has now been determined. This is a major technical feat in protein X-ray microcrystallography, as these viruses are the smallest protein crystals ever used to determine atomic structure. The study reveals robust polyhedra that could be useful as delivery capsules for biopesticides and for nanobiotechnology applications such as microarrays.

Suggested Citation

  • Fasséli Coulibaly & Elaine Chiu & Keiko Ikeda & Sascha Gutmann & Peter W. Haebel & Clemens Schulze-Briese & Hajime Mori & Peter Metcalf, 2007. "The molecular organization of cypovirus polyhedra," Nature, Nature, vol. 446(7131), pages 97-101, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7131:d:10.1038_nature05628
    DOI: 10.1038/nature05628
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    Cited by:

    1. Jeremy R. Keown & Adam D. Crawshaw & Jose Trincao & Loïc Carrique & Richard J. Gildea & Sam Horrell & Anna J. Warren & Danny Axford & Robin Owen & Gwyndaf Evans & Annie Bézier & Peter Metcalf & Jonath, 2023. "Atomic structure of a nudivirus occlusion body protein determined from a 70-year-old crystal sample," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Robert Schönherr & Juliane Boger & J. Mia Lahey-Rudolph & Mareike Harms & Jacqueline Kaiser & Sophie Nachtschatt & Marla Wobbe & Rainer Duden & Peter König & Gleb Bourenkov & Thomas R. Schneider & Lar, 2024. "A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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