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Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Author

Listed:
  • Sheli R. Radoshitzky

    (Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA)

  • Jonathan Abraham

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Christina F. Spiropoulou

    (Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA)

  • Jens H. Kuhn

    (Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany)

  • Dan Nguyen

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Wenhui Li

    (Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA)

  • Jane Nagel

    (Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA)

  • Paul J. Schmidt

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jack H. Nunberg

    (Montana Biotechnology Center, The University of Montana, Missoula, Montana 59812, USA)

  • Nancy C. Andrews

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Michael Farzan

    (Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA)

  • Hyeryun Choe

    (Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Viral receptor identified The transferrin receptor 1 (TfR1) has been identified as the cellular receptor for four New World arenaviruses — the Junin, Machupo, Guanarito and Sabia viruses. This class of arenaviruses is important because they cause fatal haemorrhagic fevers. Treating cultured cells with an antibody against TfR1 blocks viral entry and replication. Antibodies that limit arenavirus replication without interfering with host iron metabolism may be effective in controlling outbreaks of New World haemorrhagic fever.

Suggested Citation

  • Sheli R. Radoshitzky & Jonathan Abraham & Christina F. Spiropoulou & Jens H. Kuhn & Dan Nguyen & Wenhui Li & Jane Nagel & Paul J. Schmidt & Jack H. Nunberg & Nancy C. Andrews & Michael Farzan & Hyeryu, 2007. "Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses," Nature, Nature, vol. 446(7131), pages 92-96, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7131:d:10.1038_nature05539
    DOI: 10.1038/nature05539
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    Cited by:

    1. Maayan Eilon-Ashkenazy & Hadas Cohen-Dvashi & Sarah Borni & Ron Shaked & Rivka Calinsky & Yaakov Levy & Ron Diskin, 2024. "The structure of the Lujo virus spike complex," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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