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Pathogenesis and therapy of psoriasis

Author

Listed:
  • Michelle A. Lowes

    (Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA.)

  • Anne M. Bowcock

    (Washington University, School of Medicine)

  • James G. Krueger

    (Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA.)

Abstract

Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.

Suggested Citation

  • Michelle A. Lowes & Anne M. Bowcock & James G. Krueger, 2007. "Pathogenesis and therapy of psoriasis," Nature, Nature, vol. 445(7130), pages 866-873, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7130:d:10.1038_nature05663
    DOI: 10.1038/nature05663
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    Cited by:

    1. Zhikai Wang & Yang Sun & Fangzhou Lou & Jing Bai & Hong Zhou & Xiaojie Cai & Libo Sun & Qianqian Yin & Sibei Tang & Yue Wu & Li Fan & Zhenyao Xu & Hong Wang & Xiaoyu Hu & Honglin Wang, 2022. "Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Yue Li & ShiHui Wang & YouHua Zhang & ZhaoYuan Liu & YunZhe Zheng & Kun Zhang & ShiYang Chen & XiaoYing Lv & MengWen Huang & XingChao Pan & YaJuan Zheng & MengYa Yuan & GaoXiang Ge & Yi Arial Zeng & C, 2024. "Ca2+ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Juan Luis Sanz-Cabanillas & Juan Ruano & Francisco Gomez-Garcia & Patricia Alcalde-Mellado & Jesus Gay-Mimbrera & Macarena Aguilar-Luque & Beatriz Maestre-Lopez & Marcelino Gonzalez-Padilla & Pedro J , 2017. "Author-paper affiliation network architecture influences the methodological quality of systematic reviews and meta-analyses of psoriasis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-14, April.

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