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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

Author

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  • Popi Syntichaki

    (Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 71110, Crete, Greece)

  • Kostoula Troulinaki

    (Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 71110, Crete, Greece)

  • Nektarios Tavernarakis

    (Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion 71110, Crete, Greece)

Abstract

A new factor in ageing Ageing in many organisms, including humans, is accompanied by marked alterations in protein synthesis, though whether these alterations are a by-product of the ageing process or have a causative role in senescent decline is not clear. The eukaryotic initiation factor 4E (eIF4E) is a principal regulator of protein synthesis, and it has now been found to be part of a pathway influencing ageing in the nematode Caenorhabditis elegans. Specifically, depletion of a form of eIF4E found in somatic cells (body cells) of C. elegans extends lifespan, reduces protein synthesis and protects from oxidative stress. The finding suggests that eIF4E may be part of a mechanism that modulates tissue ageing by integrating environmental, reproductive and other cues to regulate protein synthesis and tissue maintenance.

Suggested Citation

  • Popi Syntichaki & Kostoula Troulinaki & Nektarios Tavernarakis, 2007. "eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans," Nature, Nature, vol. 445(7130), pages 922-926, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7130:d:10.1038_nature05603
    DOI: 10.1038/nature05603
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    1. Samim Sharifi & Prerana Chaudhari & Asya Martirosyan & Alexander Otto Eberhardt & Finja Witt & André Gollowitzer & Lisa Lange & Yvonne Woitzat & Eberechukwu Maryann Okoli & Huahui Li & Norman Rahnis &, 2024. "Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Harper S. Kim & Danitra J. Parker & Madison M. Hardiman & Erin Munkácsy & Nisi Jiang & Aric N. Rogers & Yidong Bai & Colin Brent & James A. Mobley & Steven N. Austad & Andrew M. Pickering, 2023. "Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Cyril Statzer & Jin Meng & Richard Venz & Monet Bland & Stacey Robida-Stubbs & Krina Patel & Dunja Petrovic & Raffaella Emsley & Pengpeng Liu & Ianessa Morantte & Cole Haynes & William B. Mair & Alban, 2022. "ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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