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Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript

Author

Listed:
  • Igor Martianov

    (University of Oxford
    Institut de Génétique et de Biologie Moléculaire et Cellulaire)

  • Aroul Ramadass

    (University of Oxford)

  • Ana Serra Barros

    (University of Oxford
    University of Aveiro)

  • Natalie Chow

    (University of Oxford)

  • Alexandre Akoulitchev

    (University of Oxford)

Abstract

Another angle on RNA In recent years it has become clear that non-coding RNAs (that is, RNAs that are not translated into proteins) play a vital role in regulating gene expression. A previously unknown manifestation of that control has been found to operate on the human dihydrofolate reductase (DHFR) gene. The interfering RNA forms a complex with the DHFR gene's promoter region, and in so doing it interferes with the binding of transcription factors. The non-coding RNA is produced only in quiescent cells, leading to repression of the DHFR gene in these conditions.

Suggested Citation

  • Igor Martianov & Aroul Ramadass & Ana Serra Barros & Natalie Chow & Alexandre Akoulitchev, 2007. "Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript," Nature, Nature, vol. 445(7128), pages 666-670, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7128:d:10.1038_nature05519
    DOI: 10.1038/nature05519
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    Cited by:

    1. Xiaoyu Zhang & Tianyi Ding & Fan Yang & Jixing Zhang & Haowen Xu & Yiran Bai & Yibing Shi & Jiaqi Yang & Chaoqun Chen & Chengbo Zhu & He Zhang, 2024. "Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving tumorigenesis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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