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Termination of asymmetric cell division and differentiation of stomata

Author

Listed:
  • Lynn Jo Pillitteri

    (University of Washington)

  • Daniel B. Sloan

    (University of Washington)

  • Naomi L. Bogenschutz

    (University of Washington)

  • Keiko U. Torii

    (University of Washington
    University of Washington
    CREST, Japan Science and Technology Agency)

Abstract

Stomata consist of a pair of guard cells that mediate gas and water-vapour exchange between plants and the atmosphere. Stomatal precursor cells—meristemoids—possess a transient stem-cell-like property and undergo several rounds of asymmetric divisions before further differentiation. Here we report that the Arabidopsis thaliana basic helix–loop–helix (bHLH) protein MUTE is a key switch for meristemoid fate transition. In the absence of MUTE, meristemoids abort after excessive asymmetric divisions and fail to differentiate stomata. Constitutive overexpression of MUTE directs the entire epidermis to adopt guard cell identity. MUTE has two paralogues: FAMA, a regulator of guard cell morphogenesis, and SPEECHLESS (SPCH). We show that SPCH directs the first asymmetric division that initiates stomatal lineage. Together, SPCH, MUTE and FAMA bHLH proteins control stomatal development at three consecutive steps: initiation, meristemoid differentiation and guard cell morphogenesis. Our findings highlight the roles of closely related bHLHs in cell type differentiation in plants and animals.

Suggested Citation

  • Lynn Jo Pillitteri & Daniel B. Sloan & Naomi L. Bogenschutz & Keiko U. Torii, 2007. "Termination of asymmetric cell division and differentiation of stomata," Nature, Nature, vol. 445(7127), pages 501-505, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7127:d:10.1038_nature05467
    DOI: 10.1038/nature05467
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    Cited by:

    1. Ayami Nakagawa & Krishna Mohan Sepuru & Shu Jan Yip & Hyemin Seo & Calvin M. Coffin & Kota Hashimoto & Zixuan Li & Yasutomo Segawa & Rie Iwasaki & Hiroe Kato & Daisuke Kurihara & Yusuke Aihara & Steph, 2024. "Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Wen Shi & Lingyan Wang & Lianmei Yao & Wei Hao & Chao Han & Min Fan & Wenfei Wang & Ming-Yi Bai, 2022. "Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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