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Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

Author

Listed:
  • Darwyn Kobasa

    (Public Health Agency of Canada)

  • Steven M. Jones

    (Public Health Agency of Canada
    University of Manitoba)

  • Kyoko Shinya

    (Tottori University)

  • John C. Kash

    (University of Washington)

  • John Copps

    (Canadian Food Inspection Agency, Canadian Science Centre for Human and Animal Health)

  • Hideki Ebihara

    (Public Health Agency of Canada
    University of Tokyo
    University of Tokyo
    CREST, Japan Science and Technology Agency)

  • Yasuko Hatta

    (University of Wisconsin-Madison)

  • Jin Hyun Kim

    (University of Wisconsin-Madison)

  • Peter Halfmann

    (University of Wisconsin-Madison)

  • Masato Hatta

    (University of Wisconsin-Madison)

  • Friederike Feldmann

    (Public Health Agency of Canada)

  • Judie B. Alimonti

    (Public Health Agency of Canada)

  • Lisa Fernando

    (Public Health Agency of Canada)

  • Yan Li

    (Public Health Agency of Canada)

  • Michael G. Katze

    (University of Washington
    University of Washington)

  • Heinz Feldmann

    (Public Health Agency of Canada
    University of Manitoba)

  • Yoshihiro Kawaoka

    (University of Tokyo
    University of Tokyo
    CREST, Japan Science and Technology Agency
    University of Wisconsin-Madison)

Abstract

The deadly 1918 flu virus The 1918 'Spanish flu' influenza pandemic was unusually severe, causing about 50 million deaths. Why was it so destructive? The lack of antibiotics to fight secondary infections, and socioeconomic factors may be relevant. But experimental infection of nonhuman primates with reconstructed 1918 virus suggests that the lethal nature of the virus itself was a big factor. It is in fact the only influenza virus lethal to experimentally infected nonhuman primates, and the 1918 virus, unlike other strains, suppresses innate immune responses. The H5N1 viruses now circulating cause a severe lung infection similar to that caused by the 1918 virus and also suppress innate immunity, so therapies that protect this type of host immunity might reduce the severity of infection due to these influenza viruses.

Suggested Citation

  • Darwyn Kobasa & Steven M. Jones & Kyoko Shinya & John C. Kash & John Copps & Hideki Ebihara & Yasuko Hatta & Jin Hyun Kim & Peter Halfmann & Masato Hatta & Friederike Feldmann & Judie B. Alimonti & Li, 2007. "Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus," Nature, Nature, vol. 445(7125), pages 319-323, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7125:d:10.1038_nature05495
    DOI: 10.1038/nature05495
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    Cited by:

    1. Enrique Acosta & Stacey A. Hallman & Lisa Y. Dillon & Nadine Ouellette & Robert Bourbeau & D. Ann Herring & Kris Inwood & David J. D. Earn & Joaquin Madrenas & Matthew S. Miller & Alain Gagnon, 2019. "Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959–2016," Demography, Springer;Population Association of America (PAA), vol. 56(5), pages 1723-1746, October.
    2. C. Justin Cook & Jason M. Fletcher & Angela Forgues, 2019. "Multigenerational Effects of Early-Life Health Shocks," Demography, Springer;Population Association of America (PAA), vol. 56(5), pages 1855-1874, October.
    3. Boberg-Fazlic, Nina & Ivets, Maryna & Karlsson, Martin & Nilsson, Therese, 2017. "Disease and Fertility: Evidence from the 1918 Influenza Pandemic in Sweden," Working Paper Series 1179, Research Institute of Industrial Economics.
    4. Alex Huynh & Aaron Bruhn & Bridget Browne, 2013. "A Review of Catastrophic Risks for Life Insurers," Risk Management and Insurance Review, American Risk and Insurance Association, vol. 16(2), pages 233-266, September.
    5. Boberg-Fazlic, Nina & Ivets, Maryna & Karlsson, Martin & Nilsson, Therese, 2021. "Disease and fertility: Evidence from the 1918–19 influenza pandemic in Sweden," Economics & Human Biology, Elsevier, vol. 43(C).

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