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A stomatin-domain protein essential for touch sensation in the mouse

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Listed:
  • Christiane Wetzel

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Jing Hu

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Dieter Riethmacher

    (Universität Hamburg)

  • Anne Benckendorff

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Lena Harder

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Andreas Eilers

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Rabih Moshourab

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Alexey Kozlenkov

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Dominika Labuz

    (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Ombretta Caspani

    (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Bettina Erdmann

    (Electronmicroscopy, Max-Delbrück Center for Molecular Medicine)

  • Halina Machelska

    (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Paul A. Heppenstall

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
    Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Gary R. Lewin

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

Abstract

Touch base The sense of touch is mediated by the many mechanoreceptors present in the skin. Now, for first time in a vertebrate, a single molecule whose function is necessary for this primary transduction event has been identified. The membrane protein SLP3 is necessary for mechanoreceptor function in mice in vivo, and is also required for mechanosensitive channels to function. SLP3 also modulates ion channels previously implicated in touch sensation, so may be a subunit of the mammalian touch transducer.

Suggested Citation

  • Christiane Wetzel & Jing Hu & Dieter Riethmacher & Anne Benckendorff & Lena Harder & Andreas Eilers & Rabih Moshourab & Alexey Kozlenkov & Dominika Labuz & Ombretta Caspani & Bettina Erdmann & Halina , 2007. "A stomatin-domain protein essential for touch sensation in the mouse," Nature, Nature, vol. 445(7124), pages 206-209, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7124:d:10.1038_nature05394
    DOI: 10.1038/nature05394
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    Cited by:

    1. Julia Ojeda-Alonso & Laura Calvo-Enrique & Ricardo Paricio-Montesinos & Rakesh Kumar & Ming-Dong Zhang & James F. A. Poulet & Patrik Ernfors & Gary R. Lewin, 2024. "Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    3. Chen Huang & Pei-Yi Sun & Yiming Jiang & Yuandong Liu & Zhichao Liu & Shao-Ling Han & Bao-Shan Wang & Yong-Xin Huang & An-Ran Ren & Jian-Fei Lu & Qin Jiang & Ying Li & Michael X. Zhu & Zhirong Yao & Y, 2024. "Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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