IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v445y2007i7124d10.1038_nature05394.html
   My bibliography  Save this article

A stomatin-domain protein essential for touch sensation in the mouse

Author

Listed:
  • Christiane Wetzel

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Jing Hu

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Dieter Riethmacher

    (Universität Hamburg)

  • Anne Benckendorff

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Lena Harder

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Andreas Eilers

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Rabih Moshourab

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Alexey Kozlenkov

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

  • Dominika Labuz

    (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Ombretta Caspani

    (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Bettina Erdmann

    (Electronmicroscopy, Max-Delbrück Center for Molecular Medicine)

  • Halina Machelska

    (Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Paul A. Heppenstall

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin
    Charité Universitätsmedizin Berlin, Campus Benjamin Franklin)

  • Gary R. Lewin

    (Max-Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin)

Abstract

Touch base The sense of touch is mediated by the many mechanoreceptors present in the skin. Now, for first time in a vertebrate, a single molecule whose function is necessary for this primary transduction event has been identified. The membrane protein SLP3 is necessary for mechanoreceptor function in mice in vivo, and is also required for mechanosensitive channels to function. SLP3 also modulates ion channels previously implicated in touch sensation, so may be a subunit of the mammalian touch transducer.

Suggested Citation

  • Christiane Wetzel & Jing Hu & Dieter Riethmacher & Anne Benckendorff & Lena Harder & Andreas Eilers & Rabih Moshourab & Alexey Kozlenkov & Dominika Labuz & Ombretta Caspani & Bettina Erdmann & Halina , 2007. "A stomatin-domain protein essential for touch sensation in the mouse," Nature, Nature, vol. 445(7124), pages 206-209, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7124:d:10.1038_nature05394
    DOI: 10.1038/nature05394
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05394
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05394?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    2. Chen Huang & Pei-Yi Sun & Yiming Jiang & Yuandong Liu & Zhichao Liu & Shao-Ling Han & Bao-Shan Wang & Yong-Xin Huang & An-Ran Ren & Jian-Fei Lu & Qin Jiang & Ying Li & Michael X. Zhu & Zhirong Yao & Y, 2024. "Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Julia Ojeda-Alonso & Laura Calvo-Enrique & Ricardo Paricio-Montesinos & Rakesh Kumar & Ming-Dong Zhang & James F. A. Poulet & Patrik Ernfors & Gary R. Lewin, 2024. "Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:445:y:2007:i:7124:d:10.1038_nature05394. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.