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Identification and expansion of human colon-cancer-initiating cells

Author

Listed:
  • Lucia Ricci-Vitiani

    (Istituto Superiore di Sanità)

  • Dario G. Lombardi

    (Mediterranean Institute of Oncology)

  • Emanuela Pilozzi

    (University ‘La Sapienza’)

  • Mauro Biffoni

    (Istituto Superiore di Sanità)

  • Matilde Todaro

    (University of Palermo)

  • Cesare Peschle

    (Istituto Superiore di Sanità)

  • Ruggero De Maria

    (Istituto Superiore di Sanità
    Mediterranean Institute of Oncology)

Abstract

Cancer stem cells Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells.

Suggested Citation

  • Lucia Ricci-Vitiani & Dario G. Lombardi & Emanuela Pilozzi & Mauro Biffoni & Matilde Todaro & Cesare Peschle & Ruggero De Maria, 2007. "Identification and expansion of human colon-cancer-initiating cells," Nature, Nature, vol. 445(7123), pages 111-115, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7123:d:10.1038_nature05384
    DOI: 10.1038/nature05384
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    Cited by:

    1. Nikolay Bessonov & Guillaume Pinna & Andrey Minarsky & Annick Harel-Bellan & Nadya Morozova, 2019. "Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-24, November.
    2. Mikhail Langovoy & Olaf Wittich, 2013. "Randomized algorithms for statistical image analysis and site percolation on square lattices," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 67(3), pages 337-353, August.

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