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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Author

Listed:
  • Catherine A. O’Brien

    (University Health Network)

  • Aaron Pollett

    (Department of Pathology and Laboratory Medicine)

  • Steven Gallinger

    (Mount Sinai Hospital)

  • John E. Dick

    (University Health Network
    University of Toronto)

Abstract

Cancer stem cells Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells.

Suggested Citation

  • Catherine A. O’Brien & Aaron Pollett & Steven Gallinger & John E. Dick, 2007. "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice," Nature, Nature, vol. 445(7123), pages 106-110, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7123:d:10.1038_nature05372
    DOI: 10.1038/nature05372
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    Cited by:

    1. Yan Gu & Yanrong Chen & Lai Wei & Shuang Wu & Kaicheng Shen & Chengxiang Liu & Yan Dong & Yang Zhao & Yue Zhang & Chi Zhang & Wenling Zheng & Jiangyi He & Yunlong Wang & Yifei Li & Xiaoxin Zhao & Hong, 2021. "ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Nikolay Bessonov & Guillaume Pinna & Andrey Minarsky & Annick Harel-Bellan & Nadya Morozova, 2019. "Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-24, November.
    3. Sefora Conti & Valeria Venturini & Adrià Cañellas-Socias & Carme Cortina & Juan F. Abenza & Camille Stephan-Otto Attolini & Emily Middendorp Guerra & Catherine K. Xu & Jia Hui Li & Leone Rossetti & Gi, 2024. "Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Kamyab Karimi & Ali Ghodratnama & Reza Tavakkoli-Moghaddam, 2023. "Two new feature selection methods based on learn-heuristic techniques for breast cancer prediction: a comprehensive analysis," Annals of Operations Research, Springer, vol. 328(1), pages 665-700, September.

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