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Essential role for collectrin in renal amino acid transport

Author

Listed:
  • Ursula Danilczyk

    (IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences)

  • Renu Sarao

    (IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences)

  • Christine Remy

    (University of Zurich)

  • Chahira Benabbas

    (University of Zurich)

  • Gerti Stange

    (University of Zurich)

  • Andreas Richter

    (University of Vienna)

  • Sudha Arya

    (The Hospital for Sick Children)

  • J. Andrew Pospisilik

    (IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences)

  • Dustin Singer

    (University of Zurich)

  • Simone M. R. Camargo

    (University of Zurich)

  • Victoria Makrides

    (University of Zurich)

  • Tamara Ramadan

    (University of Zurich)

  • Francois Verrey

    (University of Zurich)

  • Carsten A. Wagner

    (University of Zurich)

  • Josef M. Penninger

    (IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences)

Abstract

Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals1,2,3. A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been identified in immediate proximity to the ace2 locus4. The in vivo function of collectrin was unclear. Here we report that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney. Collectrin associates with multiple apical transporters and defines a novel group of renal amino acid transporters. Expression of collectrin in Xenopus oocytes and Madin–Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B0AT1. These data identify collectrin as a key regulator of renal amino acid uptake.

Suggested Citation

  • Ursula Danilczyk & Renu Sarao & Christine Remy & Chahira Benabbas & Gerti Stange & Andreas Richter & Sudha Arya & J. Andrew Pospisilik & Dustin Singer & Simone M. R. Camargo & Victoria Makrides & Tama, 2006. "Essential role for collectrin in renal amino acid transport," Nature, Nature, vol. 444(7122), pages 1088-1091, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7122:d:10.1038_nature05475
    DOI: 10.1038/nature05475
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    Cited by:

    1. Junyang Xu & Ziwei Hu & Lu Dai & Aditya Yadav & Yashan Jiang & Angelika Bröer & Michael G. Gardiner & Malcolm McLeod & Renhong Yan & Stefan Bröer, 2024. "Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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