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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

Author

Listed:
  • John Ridgway

    (Tumor Biology & Angiogenesis)

  • Gu Zhang

    (Tumor Biology & Angiogenesis)

  • Yan Wu

    (Antibody Engineering)

  • Scott Stawicki

    (Antibody Engineering)

  • Wei-Ching Liang

    (Antibody Engineering)

  • Yvan Chanthery

    (Tumor Biology & Angiogenesis)

  • Joe Kowalski

    (Tumor Biology & Angiogenesis)

  • Ryan J. Watts

    (Tumor Biology & Angiogenesis)

  • Christopher Callahan

    (Pathology)

  • Ian Kasman

    (Pathology)

  • Mallika Singh

    (Molecular Biology, Genentech, Inc.)

  • May Chien

    (Molecular Biology, Genentech, Inc.)

  • Christine Tan

    (Antibody Engineering)

  • Jo-Anne S. Hongo

    (Antibody Engineering)

  • Fred de Sauvage

    (Molecular Biology, Genentech, Inc.)

  • Greg Plowman

    (Tumor Biology & Angiogenesis)

  • Minhong Yan

    (Tumor Biology & Angiogenesis)

Abstract

Blood line VEGF, or vascular endothelial growth factor, is the best-characterized inducer of tumour angiogenesis, and the blockade of VEGF has become an important tool in cancer therapy. But VEGF blockade is not effective against all tumours, so the search for alternative approaches continues. Two groups this week report that one such alternative could be blockade of Dll4, Delta-like ligand 4. This transmembrane molecule is part of the Notch signalling pathway. It was known to be essential for normal development of blood vessels in the embryo: the new work shows that it is also required for tumour angiogenesis. It may be a viable — and potentially well tolerated — alternative in patients with solid tumours that are resistant to anti-VEGF therapy.

Suggested Citation

  • John Ridgway & Gu Zhang & Yan Wu & Scott Stawicki & Wei-Ching Liang & Yvan Chanthery & Joe Kowalski & Ryan J. Watts & Christopher Callahan & Ian Kasman & Mallika Singh & May Chien & Christine Tan & Jo, 2006. "Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis," Nature, Nature, vol. 444(7122), pages 1083-1087, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7122:d:10.1038_nature05313
    DOI: 10.1038/nature05313
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    Cited by:

    1. Monika A Jarzabek & William R Proctor & Jennifer Vogt & Rupal Desai & Patrick Dicker & Gary Cain & Rajiv Raja & Jens Brodbeck & Dale Stevens & Eric P van der Stok & John W M Martens & Cornelis Verhoef, 2018. "Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-20, June.
    2. Hanlin Lu & Peidong Yuan & Xiaoping Ma & Xiuxin Jiang & Shaozhuang Liu & Chang Ma & Sjaak Philipsen & Qunye Zhang & Jianmin Yang & Feng Xu & Cheng Zhang & Yun Zhang & Wencheng Zhang, 2023. "Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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