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Gut hormones and the regulation of energy homeostasis

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  • Kevin G. Murphy

    (Imperial College Faculty of Medicine, Hammersmith Campus)

  • Stephen R. Bloom

    (Imperial College Faculty of Medicine, Hammersmith Campus)

Abstract

Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy balance to key brain regions, including the hypothalamus and brainstem. Hunger and satiety represent coordinated responses to these signals, which include neural and hormonal messages from the gut. In recent years our understanding of how neural and hormonal brain–gut signalling regulates energy homeostasis has advanced considerably. Gut hormones have various physiological functions that include specifically targeting the brain to regulate appetite. New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs.

Suggested Citation

  • Kevin G. Murphy & Stephen R. Bloom, 2006. "Gut hormones and the regulation of energy homeostasis," Nature, Nature, vol. 444(7121), pages 854-859, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05484
    DOI: 10.1038/nature05484
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    Cited by:

    1. Aurélie Nakamura & Olivier François & Johanna Lepeule, 2021. "Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review," IJERPH, MDPI, vol. 18(10), pages 1-19, May.

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