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Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

Author

Listed:
  • Corey R. Mandel

    (Columbia University)

  • Syuzo Kaneko

    (Columbia University)

  • Hailong Zhang

    (Columbia University
    Array BioPharma Inc.)

  • Damara Gebauer

    (Columbia University
    Johnson & Johnson Pharmaceutical Research & Development LLC)

  • Vasupradha Vethantham

    (Columbia University)

  • James L. Manley

    (Columbia University)

  • Liang Tong

    (Columbia University)

Abstract

The crystal structure of CPSF-73, part of a complex involved in mRNA cleavage and polyadenylation is solved. CPSF-73 was purified and shown to endonucleolytically cleave mRNA, in a reaction mediated by two zinc ligands.

Suggested Citation

  • Corey R. Mandel & Syuzo Kaneko & Hailong Zhang & Damara Gebauer & Vasupradha Vethantham & James L. Manley & Liang Tong, 2006. "Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease," Nature, Nature, vol. 444(7121), pages 953-956, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05363
    DOI: 10.1038/nature05363
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    Cited by:

    1. Emily Kunce Stroup & Zhe Ji, 2023. "Deep learning of human polyadenylation sites at nucleotide resolution reveals molecular determinants of site usage and relevance in disease," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Min-Han Lin & Madeline K. Jensen & Nathan D. Elrod & Kai-Lieh Huang & Kevin A. Welle & Eric J. Wagner & Liang Tong, 2022. "Inositol hexakisphosphate is required for Integrator function," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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