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Klotho converts canonical FGF receptor into a specific receptor for FGF23

Author

Listed:
  • Itaru Urakawa

    (Kirin Brewery Co., Ltd)

  • Yuji Yamazaki

    (Kirin Brewery Co., Ltd)

  • Takashi Shimada

    (Kirin Brewery Co., Ltd)

  • Kousuke Iijima

    (Kirin Brewery Co., Ltd)

  • Hisashi Hasegawa

    (Kirin Brewery Co., Ltd)

  • Katsuya Okawa

    (Kirin Brewery Co., Ltd)

  • Toshiro Fujita

    (University of Tokyo Hospital)

  • Seiji Fukumoto

    (University of Tokyo Hospital)

  • Takeyoshi Yamashita

    (Kirin Brewery Co., Ltd)

Abstract

Anti-ageing hormone The klotho gene was first identified as a mutation in a mouse strain that exhibits a syndrome resembling human ageing, and overexpression of klotho extends the lifespan of mice. A possible mechanism of action for the Klotho protein has now been found: it converts FGFR1(IIIc), a receptor for various fibroblast growth factors acting at a local level, into a specific receptor for FGF23, a bone-derived hormone that regulates kidney function.

Suggested Citation

  • Itaru Urakawa & Yuji Yamazaki & Takashi Shimada & Kousuke Iijima & Hisashi Hasegawa & Katsuya Okawa & Toshiro Fujita & Seiji Fukumoto & Takeyoshi Yamashita, 2006. "Klotho converts canonical FGF receptor into a specific receptor for FGF23," Nature, Nature, vol. 444(7120), pages 770-774, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7120:d:10.1038_nature05315
    DOI: 10.1038/nature05315
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    Cited by:

    1. Hirokazu Sakan & Kimihiko Nakatani & Osamu Asai & Akihiro Imura & Tomohiro Tanaka & Shuhei Yoshimoto & Noriyuki Iwamoto & Norio Kurumatani & Masayuki Iwano & Yo-ichi Nabeshima & Noboru Konishi & Yoshi, 2014. "Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.

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