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Protein delivery into eukaryotic cells by type III secretion machines

Author

Listed:
  • Jorge E. Galán

    (Yale University School of Medicine, Boyer Center for Molecular Medicine)

  • Hans Wolf-Watz

    (Umea University)

Abstract

Proteins to go The type III secretion system (T3SS) is a bacterial organelle that delivers bacterial proteins into eukaryotic cells. First identified in pathogens, genome scanning has revealed these machines in many other bacteria that are symbiotic or pathogenic for animals or plants. Jorge Galán and Hans Wolf-Watz review recent work on the mechanism of T3SS action. Its presence in pathogens makes it a possible target for novel antimicrobial strategies, and these machines might also be harnessed to deliver proteins for therapeutic or vaccine purposes.

Suggested Citation

  • Jorge E. Galán & Hans Wolf-Watz, 2006. "Protein delivery into eukaryotic cells by type III secretion machines," Nature, Nature, vol. 444(7119), pages 567-573, November.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7119:d:10.1038_nature05272
    DOI: 10.1038/nature05272
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    Cited by:

    1. Sara Saleh & Sandra Van Puyvelde & An Staes & Evy Timmerman & Barbara Barbé & Jan Jacobs & Kris Gevaert & Stijn Deborggraeve, 2019. "Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 13(5), pages 1-16, May.
    2. Shiyang Cao & Tong Wang & Yifan Ren & Gengshan Wu & Yuan Zhang & Yafang Tan & Yazhou Zhou & Hongyan Chen & Yu Zhang & Yajun Song & Ruifu Yang & Zongmin Du, 2024. "A protein O-GlcNAc glycosyltransferase regulates the antioxidative response in Yersinia pestis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Vishnu Raman & Nele Van Dessel & Christopher L. Hall & Victoria E. Wetherby & Samantha A. Whitney & Emily L. Kolewe & Shoshana M. K. Bloom & Abhinav Sharma & Jeanne A. Hardy & Mathieu Bollen & Aleyde , 2021. "Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Yejun Wang & Ming'an Sun & Hongxia Bao & Aaron P White, 2013. "T3_MM: A Markov Model Effectively Classifies Bacterial Type III Secretion Signals," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-12, March.
    5. Lisa M Schechter & Joy C Valenta & David J Schneider & Alan Collmer & Eric Sakk, 2012. "Functional and Computational Analysis of Amino Acid Patterns Predictive of Type III Secretion System Substrates in Pseudomonas syringae," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-13, April.

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